Genetic Intervention on Human Subjects

Protection of human subjects in intervention research for suicidal behavior.

OBJECTIVE Three domains of ethical conduct outlined in the U.S. Food and Drug Administration's 1998 Belmont Report on protection of human research subjects-respect for persons, beneficence, and justice-have posed specific dilemmas in the design of intervention studies for suicidal behavior. These issues include questions about suicidal patients' capacity to provide informed consent, the risk of...

Experimenting on human subjects.

Rethinking risks to human subjects in genetic research.

Although the concern of biomedical researchers for the well-being of human subjects is as old as research itself, the modern era has a well-defined beginning. The horrors conducted by the Nazi doctors under the name of research led directly to the drafting in 1946 of the Nuremberg Code (1949; Annas and Grodin 1992). Only 500 words long, the document holds a hallowed place in western culture. No...

Metabolic and Genetic Screening of Electromagnetic Hypersensitive Subjects as a Feasible Tool for Diagnostics and Intervention

Growing numbers of "electromagnetic hypersensitive" (EHS) people worldwide self-report severely disabling, multiorgan, non-specific symptoms when exposed to low-dose electromagnetic radiations, often associated with symptoms of multiple chemical sensitivity (MCS) and/or other environmental "sensitivity-related illnesses" (SRI). This cluster of chronic inflammatory disorders still lacks validate...

A Review on Experimental Assessments of Pain Threshold in Healthy Human Subjects

A B S T R A C T There are three types of nerve fibers that are involved in the transmission of pain stimuli: C fibers (slower fibers) for thermal, mechanical and chemical stimuli, A-delta fibers for thermal or mechanical stimuli and A-beta fibers for touch stimuli. Clinically, this is crucial in making an accurate assessment of the pain level experienced by a suffering patient, in indicating th...